Guide 5 — pregnancy

Blood work during pregnancy: the tests and how to read them

Pregnancy brings its own blood tests, its own schedule and its own ranges. Start here to see which test comes when, and why a result that looks off may be normal for pregnancy.

Key figures

24–28
Weeks of pregnancy when most people are screened for gestational diabetes.[1]
3
Syphilis tests ACOG advises in pregnancy: first visit, third trimester and delivery.[1]
11.0 g/dL
Hemoglobin floor in the first trimester in a 2024 analysis, against 12.0 outside pregnancy.[3]
9.9%
Healthy pregnancies with platelets below 150,000 per microliter at delivery.[4]

Why pregnancy needs its own guide

Blood work during pregnancy has two jobs. Some tests look for conditions that can be treated before they affect you or the baby, such as anemia, an infection or a blood group mismatch. Others, like the glucose test in the second trimester, are screenings for problems that pregnancy itself can create.

The prenatal blood tests page walks through the whole schedule, from the first visit to the third trimester, and explains which lines on your lab report move simply because you are pregnant. Hemoglobin and platelets drift down, and creatinine falls as the kidneys filter more, so a value printed against a non-pregnant range can be flagged for no good reason.

  1. First visitBlood count, blood type and Rh factor, rubella immunity, hepatitis B and C, HIV and syphilis.
  2. Weeks 10 to 22Optional screenings for chromosomal conditions, some of them done from a simple blood draw.
  3. Weeks 24 to 28The glucose test for gestational diabetes, earlier if you have risk factors.
  4. Third trimesterA repeat syphilis test, and other checks your obstetrician or midwife decides on.

The test most people worry about

The glucose test is the one that fills forums. In the United States it usually comes in two steps: a sweet drink with a blood draw one hour later, then, if that number is high, a longer fasting test. The gestational diabetes test results page explains the cutoffs, why many people who fail the first step turn out fine, and what happens next.

Where the rest of the site helps

Pregnancy does not change how a report is laid out. The guides on reading a complete blood count, iron tests and what an out-of-range value means still apply, as long as you keep in mind that pregnancy shifts several of the numbers they discuss.

The articles in this guide

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Sources

Guidelines, consensus statements and peer-reviewed studies. Every figure on this page comes from one of them. Preprints are not cited.

  1. Patient guidance from a professional society

    Routine Tests During Pregnancy

    American College of Obstetricians and Gynecologists (ACOG) · 2024

  2. National recommendation

    Screening for Gestational Diabetes: US Preventive Services Task Force Recommendation Statement

    JAMA · 2021doi:10.1001/jama.2021.11922

  3. Observational study

    Haemoglobin thresholds to define anaemia from age 6 months to 65 years: estimates from international data sources

    The Lancet Haematology · 2024doi:10.1016/S2352-3026(24)00030-9

  4. Cohort study (7,351 women)

    Platelet Counts during Pregnancy

    The New England Journal of Medicine · 2018doi:10.1056/NEJMoa1802897